z-logo
open-access-imgOpen Access
Synthesis of High-Load, Hybrid Silica-Immobilized Heterocyclic Benzyl Phosphate (Si–OHBP) and Triazolyl Phosphate (Si–OHTP) Alkylating Reagents
Author(s) -
Saqib Faisal,
Pradip Maity,
Qin Zang,
Alan Rolfe,
Paul R. Hanson
Publication year - 2016
Publication title -
acs combinatorial science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.928
H-Index - 81
eISSN - 2156-8952
pISSN - 2156-8944
DOI - 10.1021/acscombsci.6b00042
Subject(s) - chemistry , reagent , phosphate , alkylation , combinatorial chemistry , yield (engineering) , monomer , nucleophile , silica gel , organic chemistry , catalysis , polymer , materials science , metallurgy
The development of new ROMP-derived silica-immobilized heterocyclic phosphate reagents and their application in purification-free protocols is reported. Grafting of norbornenyl norbornenyl-functionalized (Nb-tagged) silica particles with functionalized Nb-tagged heterocyclic phosphate monomers efficiently yield high-load, hybrid silica-immobilized oligomeric heterobenzyl phosphates (Si-OHBP) and heterotriazolyl phosphates (Si-OHTP) as efficient alkylation agents. Applications of these reagents for the diversification of N-, O-, and S-nucleophilic species, for efficient heterobenzylation and hetero(triazolyl)methylation have been validated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here