Open AccessClassics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases
Author(s) -
Vidya Narayanaswami,
Lindsey Drake,
Allen F. Brooks,
Jeffrey H. Meyer,
Sylvain Houle,
Michael R. Kilbourn,
Peter J. H. Scott,
Neil Vasdev
Publication year - 2019
Publication title -
acs chemical neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.158
H-Index - 69
ISSN - 1948-7193
DOI - 10.1021/acschemneuro.9b00081
Subject(s) - monoamine oxidase a , positron emission tomography , neuroimaging , monoaminergic , monoamine oxidase , monoamine oxidase b , radioligand , pet imaging , drug development , chemistry , monoamine neurotransmitter , neuroscience , pharmacology , psychology , medicine , biochemistry , enzyme , drug , receptor , serotonin
In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and -B enzyme expression or activity. MAO-A and MAO-B are critical for understanding monoaminergic pathways in psychiatric addiction disorders, and more recently in neurodegenerative disorders with MAO-B expression in astrogliosis. Unique radiochemical innovations have been shown for neuroimaging of MAOs including the clinical translation of irreversible propargylamine-based suicide inhibitors, application of deuterium-substitution to slow down metabolism, development of trapped metabolite imaging agents, and unique 11 C-carbonylation chemistry toward novel high-affinity reversibly binding inhibitors.
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