COVID-19 as a Trigger of Brain Autoimmunity | Zendy

Mayuri Gupta | Zendy; Donald F. Weaver | Zendy

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COVID-19 as a Trigger of Brain Autoimmunity

Author(s) -

Mayuri Gupta,

Donald F. Weaver

Publication year - 2021

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.1c00403

Subject(s) - neuroinflammation , neurodegeneration , molecular mimicry , autoantibody , autoimmunity , epitope , biology , bystander effect , neuroscience , immunology , microglia , effector , multiple sclerosis , neuromyelitis optica , immune system , inflammation , medicine , antibody , disease , pathology

Entry of SARS-CoV-2 into the central nervous system (CNS) activates microglia, triggering chronic neuroinflammation and possibly neurodegeneration. The complex transcriptome of SARS-CoV-2 shares molecular similarities with diverse human CNS protein epitopes, leading to a cytokine storm and various autoantibodies, potentially culminating in an autoimmune state. A COVID-19 initiated CNS autoimmune cascade may occur via multiple pathways including molecular mimicry, bystander activation, epitope spreading, production of autoantibodies, and immortalization of effector B-cells.

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