iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2 | Zendy

XiaoYuan Mao | Zendy; Weilin Jin | Zendy

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iPSCs-Derived Platform: A Feasible Tool for Probing the Neurotropism of SARS-CoV-2

Author(s) -

XiaoYuan Mao,

Weilin Jin

Publication year - 2020

Publication title -

acs chemical neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.158

H-Index - 69

ISSN - 1948-7193

DOI - 10.1021/acschemneuro.0c00512

Subject(s) - induced pluripotent stem cell , covid-19 , coronavirus , neuroscience , neurosphere , neural stem cell , virology , pandemic , medicine , biology , disease , stem cell , pathology , infectious disease (medical specialty) , microbiology and biotechnology , gene , cellular differentiation , genetics , embryonic stem cell , adult stem cell , outbreak

Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) Cell Res. DOI: 10.1038/s41422-020-0390-x).

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