Open AccessNovel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture
Author(s) -
Riley L. Svec,
Sydney A. McKee,
Matthew R. Berry,
Aya M. Kelly,
Timothy M. Fan,
Paul J. Hergenrother
Publication year - 2022
Publication title -
acs chemical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.899
H-Index - 111
eISSN - 1554-8937
pISSN - 1554-8929
DOI - 10.1021/acschembio.2c00022
Subject(s) - temozolomide , cancer research , methyltransferase , prodrug , o 6 methylguanine dna methyltransferase , dna repair , drug resistance , cancer , pharmacology , medicine , oncology , glioma , biology , dna , biochemistry , genetics , methylation
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