Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Processes | Zendy

Gregory C. Fu | Zendy

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Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S_N1 and S_N2 Processes

Author(s) -

Gregory C. Fu

Publication year - 2017

Publication title -

acs central science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.893

H-Index - 76

eISSN - 2374-7951

pISSN - 2374-7943

DOI - 10.1021/acscentsci.7b00212

Subject(s) - electrophile , sn2 reaction , enantioselective synthesis , nucleophile , nucleophilic substitution , combinatorial chemistry , chemistry , catalysis , transition metal , sn1 reaction , substitution reaction , organic chemistry

Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S N 1 and S N 2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations.

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