1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis | Zendy

Álvaro GutiérrezBonet | Zendy; John C. Tellis | Zendy; Jennifer K. Matsui | Zendy; Brandon Vara | Zendy; Gary A. Molander | Zendy

Open Access

1,4-Dihydropyridines as Alkyl Radical Precursors: Introducing the Aldehyde Feedstock to Nickel/Photoredox Dual Catalysis

Author(s) -

Álvaro GutiérrezBonet,

John C. Tellis,

Jennifer K. Matsui,

Brandon Vara,

Gary A. Molander

Publication year - 2016

Publication title -

acs catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.898

H-Index - 198

ISSN - 2155-5435

DOI - 10.1021/acscatal.6b02786

Subject(s) - alkyl , catalysis , aldehyde , electrophile , chemistry , aryl , nickel , photoredox catalysis , organic chemistry , dual (grammatical number) , combinatorial chemistry , dual role , coupling reaction , coupling (piping) , photochemistry , materials science , photocatalysis , art , literature , metallurgy

A Ni/photoredox dual catalytic cross-coupling is disclosed in which a diverse range of (hetero)aryl bromides are used as electrophiles, with 1,4-dihydropyridines serving as precursors to C sp 3 -centered alkyl radical coupling partners. The reported method is characterized by its extremely mild reaction conditions, enabling access to underexplored cores.

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