Open AccessDual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path
Author(s) -
Yaron Bram,
Xiaohua Duan,
Benjamin E. Nilsson-Payant,
Vasuretha Chandar,
Wu Hao,
Derek M. Shore,
Álvaro Fajardo,
Saloni Sinha,
Nazmul Hassan,
Harel Weinstein,
Benjamin R. tenOever,
Shuibing Chen,
Robert E. Schwartz
Publication year - 2022
Publication title -
acs bio and med chem au
Language(s) - English
Resource type - Journals
ISSN - 2694-2437
DOI - 10.1021/acsbiomedchemau.2c00034
Subject(s) - protease , allosteric regulation , computational biology , identification (biology) , drug discovery , high throughput screening , reporter gene , biology , chemistry , virology , biochemistry , enzyme , gene expression , botany , gene