Highly Protein Repellent and Antiadhesive Polysaccharide Biomaterial Coating for Urinary Catheter Applications | Zendy

Tamilselvan Mohan | Zendy; Alja Čas | Zendy; Matej Bračič | Zendy; Olivija Plohl | Zendy; Alenka Vesel | Zendy; Maja Rupnik | Zendy; Lidija Fras Zemljič | Zendy; Janez Rebol | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Highly Protein Repellent and Antiadhesive Polysaccharide Biomaterial Coating for Urinary Catheter Applications

Author(s) -

Tamilselvan Mohan,

Alja Čas,

Matej Bračič,

Olivija Plohl,

Alenka Vesel,

Maja Rupnik,

Lidija Fras Zemljič,

Janez Rebol

Publication year - 2019

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.9b01288

Subject(s) - protein adsorption , biomaterial , polydimethylsiloxane , adsorption , materials science , polymer , coating , chemistry , nanotechnology , chemical engineering , organic chemistry , engineering , composite material

Engineering functional biomaterials surfaces that resist biofilm formation triggered by unspecific protein adsorption is a key challenge, and these biosurfaces hold a huge potential in implant-associated infection. Herein, we report a water-based facile approach to install carboxylated-hyaluronic acid and sulfated-fucoidan on cationically tethered polydimethylsiloxane (PDMS) implant. We showed that these hydrophilic, charged, polysaccharide-based biosurfaces/biocoatings provide long-term stability, no adsorption of proteins (albumin and fibrinogen), similar to zwitterionic polymers, and enhanced resistance to plasma deposition and growth of Staphylococcus aureus pathogen. These findings shall pave the way in developing novel biocoatings, thereby broadening the applicability of PDMS-based implants in complex biological applications.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research