Electrochemically Modulated Nitric Oxide Release From Flexible Silicone Rubber Patch: Antimicrobial Activity For Potential Wound Healing Applications | Zendy

Woong Hee Lee | Zendy; Hang Ren | Zendy; Jianfeng Wu | Zendy; Ondřej Novák | Zendy; Richard B. Brown | Zendy; Chuanwu Xi | Zendy; Mark E. Meyerhoff | Zendy

Open Access

Electrochemically Modulated Nitric Oxide Release From Flexible Silicone Rubber Patch: Antimicrobial Activity For Potential Wound Healing Applications

Author(s) -

Woong Hee Lee,

Hang Ren,

Jianfeng Wu,

Ondřej Novák,

Richard B. Brown,

Chuanwu Xi,

Mark E. Meyerhoff

Publication year - 2016

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.6b00360

Subject(s) - polydimethylsiloxane , silicone rubber , materials science , soft lithography , antimicrobial , nitric oxide , electrode , nanotechnology , biomedical engineering , fabrication , chemistry , composite material , organic chemistry , medicine , alternative medicine , pathology

Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on both Escherichia coli and Staphylococcus aureus . The device may provide an effective, safe, and less costly alternative for treating chronic wounds.

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