Open AccessElectrochemically Modulated Nitric Oxide Release From Flexible Silicone Rubber Patch: Antimicrobial Activity For Potential Wound Healing Applications
Author(s) -
Woong Hee Lee,
Haixia Ren,
Jianfeng Wu,
Ondřej Novák,
Richard B. Brown,
Chuanwu Xi,
Mark E. Meyerhoff
Publication year - 2016
Publication title -
acs biomaterials science and engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.082
H-Index - 50
ISSN - 2373-9878
DOI - 10.1021/acsbiomaterials.6b00360
Subject(s) - polydimethylsiloxane , silicone rubber , materials science , antimicrobial , nitric oxide , soft lithography , electrode , nanotechnology , biomedical engineering , fabrication , chemistry , composite material , medicine , alternative medicine , organic chemistry , pathology
Herein, we report a novel design and the antimicrobial efficacy of a flexible nitric oxide (NO) releasing patch for potential wound healing applications. The compact sized polydimethylsiloxane (PDMS) planar patch generates NO via electrochemical reduction of nitrite ions mediated by a copper(II)-ligand catalyst using a portable power system and an internal gold coated stainless steel mesh working electrode. Patches are fabricated via soft lithography and 3-D printing. The devices can continuously release NO over 4 days and exhibit potent bactericidal effects on both Escherichia coli and Staphylococcus aureus . The device may provide an effective, safe, and less costly alternative for treating chronic wounds.