Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites | Zendy

Jorge A. Belgodere | Zendy; Dongwan Son | Zendy; Bokyoung Jeon | Zendy; Jongwon Choe | Zendy; Anna Guidry | Zendy; Adam X. Bao | Zendy; Syed A. Zamin | Zendy; Umang M. Parikh | Zendy; Swathi Balaji | Zendy; Myungwoong Kim | Zendy; Jangwook P. Jung | Zendy

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Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites

Author(s) -

Jorge A. Belgodere,

Dongwan Son,

Bokyoung Jeon,

Jongwon Choe,

Anna Guidry,

Adam X. Bao,

Syed A. Zamin,

Umang M. Parikh,

Swathi Balaji,

Myungwoong Kim,

Jangwook P. Jung

Publication year - 2021

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.1c00427

Subject(s) - gelatin , ethylene glycol , ascorbic acid , chemistry , peg ratio , antioxidant , cell adhesion , adhesion , materials science , biochemistry , organic chemistry , food science , finance , economics

We report the use of phenolic functional groups of lignosulfonate to impart antioxidant properties and the cell binding domains of gelatin to enhance cell adhesion for poly(ethylene glycol) (PEG)-based scaffolds. Chemoselective thiol-ene chemistry was utilized to form composites with thiolated lignosulfonate (TLS) and methacrylated fish gelatin (fGelMA). Antioxidant properties of TLS were not altered after thiolation and the levels of antioxidation were comparable to those of L -ascorbic acid. PEG-fGelMA-TLS composites significantly reduced the difference in COL1A1 , ACTA2 , TGFB1 , and HIF1A genes between high-scarring and low-scarring hdFBs, providing the potential utility of TLS to attenuate fibrotic responses.

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