Fabrication of Aligned Biomimetic Gellan Gum-Chitosan Microstructures through 3D Printed Microfluidic Channels and Multiple In Situ Cross-Linking Mechanisms | Zendy

Thomas M. Robinson | Zendy; Sepehr Talebian | Zendy; Javad Foroughi | Zendy; Zhilian Yue | Zendy; Cormac Fay | Zendy; Gordon G. Wallace | Zendy

Open Access

Fabrication of Aligned Biomimetic Gellan Gum-Chitosan Microstructures through 3D Printed Microfluidic Channels and Multiple In Situ Cross-Linking Mechanisms

Author(s) -

Thomas M. Robinson,

Sepehr Talebian,

Javad Foroughi,

Zhilian Yue,

Cormac Fay,

Gordon G. Wallace

Publication year - 2020

Publication title -

acs biomaterials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.082

H-Index - 50

ISSN - 2373-9878

DOI - 10.1021/acsbiomaterials.0c00260

Subject(s) - microstructure , materials science , gellan gum , fabrication , microfluidics , nanotechnology , 3d bioprinting , extrusion , 3d printing , composite material , tissue engineering , biomedical engineering , chemistry , medicine , alternative medicine , food science , pathology

In this study we use a combination of ionic- and photo-cross-linking to develop a fabrication method for producing biocompatible microstructures using a methacrylated gellan gum (a polyanion) and chitosan (a polycation) in addition to lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator. This work involves the development of a low-cost, portable 3D bioprinter and a customized extrusion mechanism for controlled introduction of the materials through a 3D printed microfluidic nozzle, before being cross-linked in situ to form robust microstructure bundles. The formed microstructures yielded a diameter of less than 1 μm and a tensile strength range of ∼1 MPa. This study is the first to explore and achieve GGMA:CHT microstructure fabrication by means of controlled in-line compaction and photo-cross-linking through 3D printed microfluidic channels.

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