Open AccessReusable Cyclodextrin-Based Electrochemical Platform for Detection oftrans-Resveratrol
Author(s) -
Zahra Panahi,
Mckenna A. Merrill,
Jeffrey Mark Halpern
Publication year - 2020
Publication title -
acs applied polymer materials
Language(s) - English
Resource type - Journals
ISSN - 2637-6105
DOI - 10.1021/acsapm.0c00866
Subject(s) - cyclodextrin , ethylene glycol , chemistry , monolayer , attenuated total reflection , polyethylene glycol , dielectric spectroscopy , polymer , contact angle , x ray photoelectron spectroscopy , supramolecular chemistry , infrared spectroscopy , polymer chemistry , organic chemistry , electrochemistry , chemical engineering , molecule , biochemistry , electrode , engineering
A reusable sensor architecture, through the combination of self-assembled monolayers and cyclodextrin supramolecular interactions, is demonstrated for class recognition of hydrophobic analytes demonstrated with trans-resveratrol. The reloadable sensor is based on reversible immobilization of α-cyclodextrin on polyethylene glycol surface. α-cyclodextrins complexes with polyethylene glycols and causes the polymer chains to change their surface configuration. The reproducibility and stability of the sur-face, in the detection of nanomolar concentrations of trans-resveratrol, can be demonstrated by electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and Attenuated total reflectance-Fourier transform infrared spectroscopy. We propose that during sensor operation, α-cyclodextrin decouples from the poly-ethylene glycol surface to complex with trans-resveratrol in solution, and after use, the surface regeneration is conducted with a simple α-cyclodextrin soak. To test the nonspecific response, the sensor was also tested with trans-resveratrol spiked human urine.