Open AccessCore (Polystyrene)–Shell [Poly(glycerol monomethacrylate)] Particles
Author(s) -
Andrew J. McKenzie,
Richard Hoskins,
Thomas Swift,
Colin A. Grant,
Stephen Rimmer
Publication year - 2017
Publication title -
acs applied materials and interfaces
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.535
H-Index - 228
eISSN - 1944-8252
pISSN - 1944-8244
DOI - 10.1021/acsami.6b15004
Subject(s) - adsorption , monomer , materials science , polystyrene , chemical engineering , emulsion polymerization , emulsion , polymer chemistry , shell (structure) , protein adsorption , aqueous solution , lysozyme , polystyrene sulfonate , chemistry , organic chemistry , polymer , layer (electronics) , nanotechnology , composite material , biochemistry , pedot:pss , engineering
A set of water-swollen core-shell particles was synthesized by emulsion polymerization of a 1,3-dioxolane functional monomer in water. After removal of the 1,3-dioxolane group, the particles' shells were shown to swell in aqueous media. Upon hydrolysis, the particles increased in size from around 70 to 100-130 nm. A bicinchoninic acid assay and ζ-potential measurements were used to investigate the adsorption of lysozyme, albumin, or fibrinogen. Each of the core-shell particles adsorbed significantly less protein than the noncoated core (polystyrene) particles. Differences were observed as both the amount of difunctional, cross-linking monomer and the amount of shell monomer in the feed were changed. The core-shell particles were shown to be resistant to protein adsorption, and the degree to which the three proteins adsorbed was dependent on the formulation of the shell.