Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents | Zendy

Liqin Zhang | Zendy; Guizhi Zhu | Zendy; Lei Mei | Zendy; Cuichen Wu | Zendy; Liping Qiu | Zendy; Cheng Cui | Zendy; Yuan Liu | Zendy; ITing Teng | Zendy; Weihong Tan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Self-Assembled DNA Immunonanoflowers as Multivalent CpG Nanoagents

Author(s) -

Liqin Zhang,

Guizhi Zhu,

Lei Mei,

Cuichen Wu,

Liping Qiu,

Cheng Cui,

Yuan Liu,

ITing Teng,

Weihong Tan

Publication year - 2015

Publication title -

acs applied materials and interfaces

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.5b06987

Subject(s) - cpg site , cpg oligodeoxynucleotide , nuclease , dna , tumor necrosis factor alpha , rolling circle replication , immune system , biology , cancer cell , guanine , microbiology and biotechnology , dna methylation , materials science , cancer research , cancer , dna replication , immunology , biochemistry , gene , nucleotide , genetics , gene expression

Synthetic unmethylated cytosine-guanine (CpG) oligodeoxynucleotides are immunostimulatory motifs that have shown promise as vaccines or adjuvants for diseases such as cancers and infectious diseases. In the present work, novel immuno-nanoflowers (NFs), self-assembled from long DNA integrated with tandem CpG through rolling circle replication, were developed for efficient CpG delivery and protection from nuclease degradation. In a model of macrophage-like cells, the CpG NFs proved to be potent immunostimulators by triggering the proliferation of these immune cells, which, in turn, secreted immunostimulatory cytokines, including tumor necrosis factor α, interleukin-6, and interleukin-10. These results demonstrate the ability of CpG NFs to induce cancer cell apoptosis and necrosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research