Open AccessPeptide-Modified Biopolymers for Biomedical Applications
Author(s) -
Jessica Hersh,
David Broyles,
José Manuel Cóndor Capcha,
Emre Dikici,
Lina A. Shehadeh,
Sylvia Daunert,
Sapna K. Deo
Publication year - 2020
Publication title -
acs applied bio materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.764
H-Index - 17
ISSN - 2576-6422
DOI - 10.1021/acsabm.0c01145
Subject(s) - biocompatibility , biomaterial , nanotechnology , scaffold , tissue engineering , biocompatible material , materials science , biomedical engineering , engineering , metallurgy
Polymeric biomaterials have been used in a variety of applications, like cargo delivery and tissue scaffolding, because they are easily synthesized and can be adapted to many systems. However, there is still a need to further enhance and improve their functions to progress their use in the biomedical field. A promising solution is to modify the polymer surfaces with peptides that can increase biocompatibility, cellular interactions, and receptor targeting. In recent years, peptide modifications have been used to overcome many challenges to polymer biomaterial development. This review discusses recent progress in developing peptide-modified polymers for therapeutic applications including cell-specific targeting and tissue engineering. Furthermore, we will explore some of the most frequently studied base components of these biomaterials.