2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents | Zendy

Sinenhlanhla N. Mthembu | Zendy; Anamika Sharma | Zendy; Fernando Alberício | Zendy; Beatriz G. de la Torre | Zendy

Open Access

2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents

Author(s) -

Sinenhlanhla N. Mthembu,

Anamika Sharma,

Fernando Alberício,

Beatriz G. de la Torre

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b04106

Subject(s) - dithiol , chemistry , disulfide bond , reagent , butane , bioconjugation , combinatorial chemistry , environmentally friendly , reducing agent , thiol , organic chemistry , catalysis , biochemistry , ecology , biology

Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synthesis of a new disulfide-reducing agent [2-(dibenzylamino)butane-1,4-dithiol (DABDT)] that is conveniently prepared from inexpensive aspartic acid. Being nonmalodorous and highly soluble in a broad range of solvents, DABDT is user-friendly. We have demonstrated its performance both in solution and in the solid phase.

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