Open AccessAsymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination
Author(s) -
Saki Ichikawa,
Stephen L. Buchwald
Publication year - 2019
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.9b03356
Subject(s) - hydroamination , chemistry , enantioselective synthesis , catalysis , copper , allylic rearrangement , intermolecular force , combinatorial chemistry , organic chemistry , amino acid , alcohol , molecule , biochemistry
Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this protocol provided an efficient one-step method for the enantioselective synthesis of γ-amino alcohols in an intermolecular manner.
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