Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl Sulfides and Its Application in Fluorescent Probe Development | Zendy

Yingying Wang | Zendy; Chuntao Yang | Zendy; Shi Xu | Zendy; Wei Chen | Zendy; Ming Xian | Zendy

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Hydrogen Sulfide Mediated Tandem Reaction of Selenenyl Sulfides and Its Application in Fluorescent Probe Development

Author(s) -

Yingying Wang,

Chuntao Yang,

Shi Xu,

Wei Chen,

Ming Xian

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b02844

Subject(s) - chemistry , hydrogen sulfide , fluorescence , tandem , sulfide , cysteine , cleavage (geology) , selectivity , combinatorial chemistry , bond cleavage , organic chemistry , photochemistry , sulfur , catalysis , enzyme , physics , engineering , composite material , materials science , geotechnical engineering , quantum mechanics , fracture (geology)

A unique reaction between H 2 S and a selenenyl sulfide containing benzoate ester template was discovered. This reaction could be specifically triggered by H 2 S and lead to ester bond cleavage. The reaction was not affected by the presence of thiols such as glutathione and cysteine. With this reaction, a series of fluorescent probes were synthesized and evaluated. The probes exhibited high sensitivity/selectivity for H 2 S in both buffers and cells.

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