Open AccessCu-Catalyzed Oxidation of C2 and C3 Alkyl-Substituted Indole via Acyl Nitroso Reagents
Author(s) -
Jun Zhang,
Saeedeh Torabi Kohlbouni,
Babak Borhan
Publication year - 2018
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.8b03185
Subject(s) - chemistry , alkyl , oxindole , amination , indole test , reagent , nitroso , catalysis , nitroso compounds , regioselectivity , combinatorial chemistry , organic chemistry , medicinal chemistry
The selective oxidation of C2-alkyl-substituted indoles to 3-oxindole and the selective C-H oxygenation or amination of C2,C3-dialkyl-substituted indoles at C2 are reported under mild conditions. The position of the alkyl substitution on the indole directs the reaction to different pathways under similar conditions.