Development of a Synthetic Receptor for the Food Toxin Beauvericin: A Tale of Carbazole and Steroids | Zendy

Vincent Ornelis | Zendy; Andreja Rajković | Zendy; Benedikt Sas | Zendy; Sarah De Saeger | Zendy; Annemieke Madder | Zendy

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Development of a Synthetic Receptor for the Food Toxin Beauvericin: A Tale of Carbazole and Steroids

Author(s) -

Vincent Ornelis,

Andreja Rajković,

Benedikt Sas,

Sarah De Saeger,

Annemieke Madder

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b02630

Subject(s) - beauvericin , valinomycin , chemistry , receptor , carbazole , toxin , selectivity , fluorescence , ionophore , stereochemistry , biophysics , biochemistry , membrane potential , photochemistry , mycotoxin , membrane , physics , food science , quantum mechanics , biology , catalysis

The synthesis of the first synthetic receptor showing high affinity for the toxic ionophoric cyclodepsipeptide beauvericin is described. Binding results in a pronounced increase in fluorescence intensity of the receptor, while this increase is not observed for a very similar ionophore such as valinomycin. Experiments that shed light on the nature of this selectivity are discussed.

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