Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting | Zendy

Peter Štacko | Zendy; Lucie Muchová | Zendy; Libor Vı́tek | Zendy; Petr Klán | Zendy

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Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting

Author(s) -

Peter Štacko,

Lucie Muchová,

Libor Vı́tek,

Petr Klán

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b02043

Subject(s) - thiocarbamate , chemistry , carbonyl sulfide , hydrogen sulfide , photochemistry , carbonic anhydrase , bodipy , visible spectrum , sulfide , in vitro , combinatorial chemistry , sulfur , biophysics , enzyme , biochemistry , organic chemistry , fluorescence , optoelectronics , physics , quantum mechanics , biology

The synthesis and photochemical properties of H 2 S-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to H 2 S using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high H 2 S release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.

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