Open AccessRuthenium(II)-Catalyzed Regio- and Stereoselective C–H Allylation of Indoles with Allyl Alcohols
Author(s) -
Xiaowei Wu,
Haitao Ji
Publication year - 2018
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.8b00567
Subject(s) - chemistry , stereoselectivity , regioselectivity , ruthenium , catalysis , organic chemistry , hydroxide , medicinal chemistry , combinatorial chemistry
A ruthenium-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination is reported. Without external oxidants and expensive additives, this reaction features mild reaction conditions, compatibility with various functional groups, and good to excellent regioselectivity and stereoselectivity.