Synthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates | Zendy

Marcus Reitti | Zendy; Ramani Gurubrahamam | Zendy; Melanie Walther | Zendy; Erik Lindstedt | Zendy; Berit Olofsson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates

Author(s) -

Marcus Reitti,

Ramani Gurubrahamam,

Melanie Walther,

Erik Lindstedt,

Berit Olofsson

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b00287

Subject(s) - chemistry , phenols , silylation , nucleophile , aryne , aryl , hydroxide , organic chemistry , reactivity (psychology) , hydrogen peroxide , combinatorial chemistry , catalysis , medicine , alkyl , alternative medicine , pathology

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research