Arynes in the Monoarylation of Unprotected Carbohydrate Amines | Zendy

Kumar Bhaskar Pal | Zendy; Mukul Mahanti | Zendy; Ulf J. Nilsson | Zendy

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Arynes in the Monoarylation of Unprotected Carbohydrate Amines

Author(s) -

Kumar Bhaskar Pal,

Mukul Mahanti,

Ulf J. Nilsson

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b03741

Subject(s) - chemistry , aryne , carbohydrate , scope (computer science) , sugar , reaction conditions , organic chemistry , combinatorial chemistry , catalysis , programming language , computer science

A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.

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