Open AccessSynthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
Author(s) -
Zhengbo Zhu,
Xin Lv,
Jason E. Anesini,
Daniel Seidel
Publication year - 2017
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b03309
Subject(s) - chemistry , pyrrolidine , piperidine , morpholine , annulation , redox , amine gas treating , cyclic amines , catalysis , organic chemistry , combinatorial chemistry
α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.
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