Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometallics | Zendy

Robert Greiner | Zendy; Dorothée Ziegler | Zendy; Denise Cibu | Zendy; Andreas C. Jakowetz | Zendy; Florian Auras | Zendy; Thomas Bein | Zendy; Paul Knochel | Zendy

Open Access

Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometallics

Author(s) -

Robert Greiner,

Dorothée Ziegler,

Denise Cibu,

Andreas C. Jakowetz,

Florian Auras,

Thomas Bein,

Paul Knochel

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b03242

Subject(s) - chemistry , halide , magnesium , zinc , sodium formate , alkyl , cobalt , catalysis , combinatorial chemistry , organic chemistry

CoCl 2 (5%) catalyzes cross-couplings of various halogenated naphthyridines with alkyl- and arylmagnesium halides. Also, arylzinc halides undergo smooth cross-couplings with various naphthyridines in the presence of CoCl 2 ·2LiCl (5%) and sodium formate (50%), leading to polyfunctional arylated naphthyridines. Two of these arylated naphthyridines are highly fluorescent, with quantum efficiencies reaching 95% and long excited-state lifetimes of up to 12 ns.

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