Open AccessAn Approach to the Core of Lactonamycin
Author(s) -
Philip J. Parsons,
Daniel R. Jones,
Lee J. Walsh,
Lewis A. T. Allen,
Ada Onwubiko,
Lewis Preece,
Johnathan Board,
Andrew J. P. White
Publication year - 2017
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b00902
Subject(s) - chemistry , core (optical fiber) , computer science , telecommunications
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.
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