Applications of Synthetic Organic Tetrasulfides as H2S Donors | Zendy

Matthew M. Cerda | Zendy; Matthew D. Hammers | Zendy; Mary S. Earp | Zendy; Lev N. Zakharov | Zendy; Michael D. Pluth | Zendy

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Applications of Synthetic Organic Tetrasulfides as H₂S Donors

Author(s) -

Matthew M. Cerda,

Matthew D. Hammers,

Mary S. Earp,

Lev N. Zakharov,

Michael D. Pluth

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b00858

Subject(s) - chemistry , alkyl , aryl , glutathione , diallyl trisulfide , organic synthesis , donation , combinatorial chemistry , organic chemistry , biochemistry , catalysis , economics , economic growth , apoptosis , enzyme

In an effort to expand the availability of simple polysulfides for H 2 S donation, we report here the synthesis and H 2 S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H 2 S in a first-order dependence on reduced glutathione (GSH) and release more H 2 S than the commonly used trisulfide DATS.

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