Open AccessApplications of Synthetic Organic Tetrasulfides as H2S Donors
Author(s) -
Matthew M. Cerda,
Matthew D. Hammers,
Mary S. Earp,
Lev N. Zakharov,
Michael D. Pluth
Publication year - 2017
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b00858
Subject(s) - chemistry , alkyl , aryl , glutathione , diallyl trisulfide , combinatorial chemistry , organic chemistry , biochemistry , apoptosis , enzyme
In an effort to expand the availability of simple polysulfides for H 2 S donation, we report here the synthesis and H 2 S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H 2 S in a first-order dependence on reduced glutathione (GSH) and release more H 2 S than the commonly used trisulfide DATS.