trans-Aminoboration across Internal Alkynes Catalyzed by B(C6F5)3 for the Synthesis of Borylated Indoles | Zendy

Kang Yuan | Zendy; Suning Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

trans-Aminoboration across Internal Alkynes Catalyzed by B(C₆F₅)₃ for the Synthesis of Borylated Indoles

Author(s) -

Kang Yuan,

Suning Wang

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b00437

Subject(s) - chemistry , catalysis , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry

We report here a facile B(C 6 F 5 ) 3 catalyzed trans-aminoboration of internal alkynes, furnishing 3-position borylated indoles at ambient temperature. This reaction proceeds with the breaking of a B-N bond and the formation of N-C and B-C bonds to produce indole and derivatives in one step. It works well for various boron reagents and alkynyl-anilines. The borylated indoles can be further derivatized to give column stable organoboron compounds that can be used for future functionalization.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research