Open AccessOne-Step Transformation of Coenzyme A into Analogues by Transamidation
Author(s) -
Randy Sanichar,
John C. Vederas
Publication year - 2017
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b00291
Subject(s) - nonribosomal peptide , chemistry , coenzyme a , combinatorial chemistry , enzyme , polyketide , acyl carrier protein , cofactor , biochemistry , catalysis , transformation (genetics) , stereochemistry , biosynthesis , reductase , gene
Several coenzyme A (CoA) analogues are made in a single step under mild conditions via transamidation reactions catalyzed by boric acid in water. This approach offers rapid access to compounds useful for the study of a wide spectrum of enzyme catalyzed reactions, especially processes involving acyl carrier proteins (ACP) of polyketide synthases (PKS), fatty acid synthases (FAS), and nonribosomal peptide synthetases (NRPS). The CoA analogues presented are readily elaborated or extended by precedented reactions for specific applications that may be required.