Open AccessDirect α-Arylation/Heteroarylation of 2-Trifluoroboratochromanones via Photoredox/Nickel Dual Catalysis
Author(s) -
Jennifer K. Matsui,
Gary A. Molander
Publication year - 2017
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b03448
Subject(s) - chemistry , chalcone , aryl , catalysis , nickel , bromide , combinatorial chemistry , ring (chemistry) , dual (grammatical number) , photoredox catalysis , organic chemistry , photocatalysis , art , alkyl , literature
Utilizing photoredox/nickel dual catalysis, diverse flavanones have been synthesized by coupling novel 2-trifluoroboratochromanone building blocks with aryl and heteroaryl bromide partners. The newly reported trifluoroboratochromanones can be easily accessed from the corresponding chromones on multigram scale. This represents a general route for accessing natural and unnatural flavanones that were previously formed through a synthetically more restrictive ring closure route from chalcone precursors.