Reduction of Selenoamides to Amines Using SmI2–H2O | Zendy

Samuel Thurow | Zendy; Eder J. Lenardão | Zendy; Xavier JustBaringo | Zendy; David J. Procter | Zendy

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Reduction of Selenoamides to Amines Using SmI₂–H₂O

Author(s) -

Samuel Thurow,

Eder J. Lenardão,

Xavier JustBaringo,

David J. Procter

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b03325

Subject(s) - chemistry , amine gas treating , alkyl , aryl , primary (astronomy) , reduction (mathematics) , tertiary amine , base (topology) , combinatorial chemistry , lewis acids and bases , medicinal chemistry , organic chemistry , catalysis , mathematical analysis , physics , geometry , mathematics , astronomy

Selenoamides are selectively reduced to amines by SmI 2 with H 2 O. The process is general for primary, secondary, and tertiary aryl and alkyl selenoamide substrates and selectively delivers amine products. The reduction proceeds under mild conditions using SmI 2 activated by straightforward addition of H 2 O, and does not require an additional Lewis base additive.

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