Open AccessConstruction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
Author(s) -
Jun Xuan,
Constantin G. Daniliuc,
Armido Studer
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b03267
Subject(s) - chemistry , catalysis , cascade , scope (computer science) , combinatorial chemistry , substrate (aquarium) , computational chemistry , organic chemistry , computer science , chromatography , programming language , oceanography , geology
Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C-C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable.