Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis | Zendy

Jun Xuan | Zendy; Constantin G. Daniliuc | Zendy; Armido Studer | Zendy

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Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis

Author(s) -

Jun Xuan,

Constantin G. Daniliuc,

Armido Studer

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b03267

Subject(s) - chemistry , catalysis , combinatorial chemistry , computational chemistry , electron , organic chemistry , quantum mechanics , physics

Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C-C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable.

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