Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides | Zendy

Liangbin Huang | Zendy; Daniel J. Weix | Zendy

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Ruthenium-Catalyzed C–H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides

Author(s) -

Liangbin Huang,

Daniel J. Weix

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b02862

Subject(s) - chemistry , aryl , ruthenium , trifluoromethanesulfonate , carboxylate , iodide , electrophile , medicinal chemistry , ligand (biochemistry) , halide , bromide , carboxylic acid , catalysis , pyridine , amide , organic chemistry , alkyl , biochemistry , receptor

Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C-H bond.

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