Open AccessTotal Synthesis of (+)-Vicenin-2
Author(s) -
Thanh C. Ho,
Haruki Kamimura,
Ken Ohmori,
Keisuke Suzuki
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b02203
Subject(s) - chemistry , yield (engineering) , glycosylation , fluorine , nucleophilic aromatic substitution , nucleophile , nucleophilic substitution , combinatorial chemistry , flavonoid , stereochemistry , organic chemistry , catalysis , biochemistry , materials science , metallurgy , antioxidant
The bis-C-glucosyl flavonoid vicenin-2 (1) has been synthesized by exploiting bis-C-glycosylation of 1,3,5-trifluorobenzene and aromatic nucleophilic substitution to transform fluorine atoms to oxygen functions in excellent yield.
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