Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans | Zendy

TzuShyang Lin | Zendy; YiMing Chiang | Zendy; Clay C. C. Wang | Zendy

Open Access

Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans

Author(s) -

TzuShyang Lin,

YiMing Chiang,

Clay C. C. Wang

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b00299

Subject(s) - aspergillus terreus , polyketide , aspergillus nidulans , polyene , heterologous expression , chemistry , polyketide synthase , aspergillus , stereochemistry , biosynthesis , heterologous , pyrone , biochemistry , natural product , gene cluster , gene , biology , microbiology and biotechnology , recombinant dna , mutant

Citreoviridin (1) belongs to a class of F1-ATPase β-subunit inhibitors that are synthesized by highly reducing polyketide synthases. These potent mycotoxins share an α-pyrone polyene structure, and they include aurovertin, verrucosidin, and asteltoxin. The identification of the citreoviridin biosynthetic gene cluster in Aspergillus terreus var. aureus and its reconstitution using heterologous expression in Aspergillus nidulans are reported. Two intermediates were isolated that allowed the proposal of the biosynthetic pathway of citreoviridin.

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