Open AccessPalladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
Author(s) -
Thomas D. Montgomery,
Viresh H. Rawal
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.5b03708
Subject(s) - chemistry , palladium , catalysis , nitrogen , propargyl , diamine , combinatorial chemistry , organic chemistry , modular design , computer science , operating system
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.