Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles | Zendy

Thomas D. Montgomery | Zendy; Viresh H. Rawal | Zendy

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Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles

Author(s) -

Thomas D. Montgomery,

Viresh H. Rawal

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b03708

Subject(s) - chemistry , palladium , catalysis , nitrogen , propargyl , diamine , combinatorial chemistry , organic chemistry , modular design , computer science , operating system

We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control.

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