Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids | Zendy

Andrew V. Mossine | Zendy; Allen F. Brooks | Zendy; Katarina J. Makaravage | Zendy; Jason Miller | Zendy; Naoko Ichiishi | Zendy; Melanie S. Sanford | Zendy; Peter J. H. Scott | Zendy

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Synthesis of [¹⁸F]Arenes via the Copper-Mediated [¹⁸F]Fluorination of Boronic Acids

Author(s) -

Andrew V. Mossine,

Allen F. Brooks,

Katarina J. Makaravage,

Jason Miller,

Naoko Ichiishi,

Melanie S. Sanford,

Peter J. H. Scott

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b02875

Subject(s) - chemistry , copper , aryl , combinatorial chemistry , functional group , stereochemistry , organic chemistry , alkyl , polymer

A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.

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