Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates | Zendy

Zhengbiao He | Zendy; Ping Tan | Zendy; Chuanfa Ni | Zendy; Jinbo Hu | Zendy

Open Access

Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates

Author(s) -

Zhengbiao He,

Ping Tan,

Chuanfa Ni,

Jinbo Hu

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b00308

Subject(s) - chemistry , conjugated system , aryl , sodium , medicinal chemistry , sodium salt , organic chemistry , combinatorial chemistry , polymer , inorganic chemistry , alkyl

Fluorinated sulfinate salts RfSO2Na (Rf = CF2H, CF2Ph, and CH2F) have been prepared via NaBH4-mediated reduction of the corresponding benzo[d]thiazol-2-yl sulfones, and their synthetic application as di- and monofluoroalkyl radical precursors is demonstrated in the silver-catalyzed cascade fluoroalkylation/aryl migration/SO2 extrusion of conjugated N-arylsulfonylated amides.

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