Open AccessTotal Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide
Author(s) -
Dancan K. Njeri,
Justin R. Ragains
Publication year - 2022
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.2c01034
Subject(s) - tetrasaccharide , acinetobacter baumannii , chemistry , glycosylation , polysaccharide , stereochemistry , total synthesis , biochemistry , combinatorial chemistry , microbiology and biotechnology , bacteria , biology , pseudomonas aeruginosa , genetics
Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2- cis -selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis.