Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide | Zendy

Dancan K. Njeri | Zendy; Justin R. Ragains | Zendy

Open Access

Total Synthesis of an All-1,2-cis-Linked Repeating Unit from the Acinetobacter baumannii D78 Capsular Polysaccharide

Author(s) -

Dancan K. Njeri,

Justin R. Ragains

Publication year - 2022

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.2c01034

Subject(s) - tetrasaccharide , acinetobacter baumannii , chemistry , glycosylation , polysaccharide , stereochemistry , total synthesis , biochemistry , combinatorial chemistry , microbiology and biotechnology , bacteria , biology , pseudomonas aeruginosa , genetics

Chemical synthetic efforts have resulted in the preparation of the assigned tetrasaccharide repeating subunit from the Acinetobacter baumannii KL4-associated capsular polysaccharide. A convergent synthetic strategy hinging on a 1,2- cis -selective [2+2] glycosylation to generate the fully protected tetrasaccharide was key to the success of this synthesis.

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