A Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes | Zendy

Ryan P. King | Zendy; Shane W. Krska | Zendy; Stephen L. Buchwald | Zendy

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A Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes

Author(s) -

Ryan P. King,

Shane W. Krska,

Stephen L. Buchwald

Publication year - 2021

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.1c02307

Subject(s) - chemistry , bioconjugation , palladium , oxidative phosphorylation , aryl , oxidative addition , combinatorial chemistry , catalysis , halide , germanium compounds , organic chemistry , germanium , biochemistry , alkyl , silicon

The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report the use of Cámpora's palladacycle as a new, more stable precursor to Pd OACs. Using this palladacycle, a series of biarylphosphine ligated OACs, including those with pharmaceutical-derived aryl halides and relevance to bioconjugation, were prepared.

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