Open AccessA Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes
Author(s) -
Ryan P. King,
Shane W. Krska,
Stephen L. Buchwald
Publication year - 2021
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.1c02101
Subject(s) - chemistry , palladium , ligand (biochemistry) , oxidative phosphorylation , combinatorial chemistry , oxidative addition , organic chemistry , catalysis , receptor , biochemistry
Palladium oxidative addition complexes (OACs) have recently emerged as useful tools to enable challenging bond connections. However, each OAC can only be formed with one dative ligand at a time. As no one ligand is optimal for every cross-coupling reaction, we herein disclose a ligand exchange protocol for the preparation of a series of OACs bearing a variety of ancillary ligands from one common complex. These complexes were further applied to cross-coupling transformations.