Rh-Catalyzed Ortho C–H Alkynylation of Aromatic Aldehydes | Zendy

Eric Tan | Zendy; Leonardo J. Nannini | Zendy; Otilia Stoica | Zendy; Antonio M. Echavarren | Zendy

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Rh-Catalyzed Ortho C–H Alkynylation of Aromatic Aldehydes

Author(s) -

Eric Tan,

Leonardo J. Nannini,

Otilia Stoica,

Antonio M. Echavarren

Publication year - 2021

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c04243

Subject(s) - alkynylation , chemistry , catalysis , imine , surface modification , combinatorial chemistry , scope (computer science) , organic chemistry , medicinal chemistry , computer science , programming language

The Rh(III)-catalyzed ortho -alkynylation of benzaldehydes is enabled by the transient formation of an imine as a directing group. A broad scope of substrates was obtained under mild reaction conditions, granting access to mono- and dialkynylated products. The functionalization of readily available building blocks allowed the development of modular syntheses of dibenzopentalenes, isoquinolines, indoles, and indolines.

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