Open AccessAccess to α-Pyrazole and α-Triazole Derivatives of Ketones from Oxidative Heteroarylation of Silyl Enolethers
Author(s) -
Sandeep Dhanju,
Aidan C. Caravana,
Regan J. Thomson
Publication year - 2020
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.0c03005
Subject(s) - chemistry , pyrazole , steric effects , ceric ammonium nitrate , silylation , oxidative phosphorylation , aromatization , oxidative coupling of methane , combinatorial chemistry , triazole , organic chemistry , medicinal chemistry , catalysis , biochemistry , grafting , polymer
The synthesis of α-pyrazole and α-triazole derivatives of ketones by the ceric ammonium nitrate-mediated oxidative coupling of enolsilanes with heteroarenes is reported. The reaction proceeds under mild reaction conditions to provide a diversity of products, including sterically hindered fully substituted derivatives.