Open AccessDirect Radiofluorination of Arene C–H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant
Author(s) -
Li Wang,
Alexander R. White,
Wei Chen,
Zhanhong Wu,
David A. Nicewicz,
Zibo Li
Publication year - 2020
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.0c02815
Subject(s) - photoredox catalysis , oxidizing agent , chemistry , combinatorial chemistry , hydrogen peroxide , peroxide , photocatalysis , catalysis , photochemistry , organic chemistry
Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.