Synthetic Studies toward the Hamigerans with a 6–7–5 Tricyclic Core | Zendy

Baiyang Jiang | Zendy; Mingji Dai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthetic Studies toward the Hamigerans with a 6–7–5 Tricyclic Core

Author(s) -

Baiyang Jiang,

Mingji Dai

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c01253

Subject(s) - chemistry , aryne , ring (chemistry) , tricyclic , isopropyl , conjugate , quaternary carbon , stereochemistry , carbon skeleton , suzuki reaction , core (optical fiber) , medicinal chemistry , combinatorial chemistry , catalysis , organic chemistry , enantioselective synthesis , mathematical analysis , palladium , materials science , mathematics , composite material

An approach toward the 6-7-5 tricyclic carbon skeleton of the hamigeran natural products was developed. The key steps include a benzyne-β-ketoester annulative ring expansion to form the 7-membered ring, a Nazarov reaction to form the 5-membered ring, a Ni-catalyzed conjugate methyl addition or a Corey-Chaykovsky reaction to install the all-carbon quaternary center, and a Suzuki cross coupling followed by reduction to introduce the isopropyl group.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research