Enantioselective Synthesis of Chiral Organofluorine Compounds: Alcohol-Mediated Hydrogen Transfer for Catalytic Carbonyl Reductive Coupling | Zendy

Johannes Tauber | Zendy; Leyah A. Schwartz | Zendy; Michael J. Krische | Zendy

Open Access

Enantioselective Synthesis of Chiral Organofluorine Compounds: Alcohol-Mediated Hydrogen Transfer for Catalytic Carbonyl Reductive Coupling

Author(s) -

Johannes Tauber,

Leyah A. Schwartz,

Michael J. Krische

Publication year - 2019

Publication title -

organic process research and development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 109

eISSN - 1520-586X

pISSN - 1083-6160

DOI - 10.1021/acs.oprd.9b00035

Subject(s) - enantioselective synthesis , alcohol , transfer hydrogenation , chemistry , catalysis , coupling (piping) , hydrogen , combinatorial chemistry , organic chemistry , materials science , ruthenium , metallurgy

Alcohol-mediated carbonyl addition has enabled catalytic enantioselective syntheses of diverse fluorine-containing compounds without the need for stoichiometric metals or discrete redox manipulations. Reactions of this type may be separated into two broad categories: redox-neutral hydrogen auto-transfer reactions wherein lower alcohols and n-unsaturated pronucleophiles are converted to higher alcohols and corresponding 2-propanol mediated carbonyl reductive couplings.

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