Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor | Zendy

Zhenghui Wen | Zendy; Apoorva Maheshwari | Zendy; Carlo Sambiagio | Zendy; Yuchao Deng | Zendy; Gabriele Laudadio | Zendy; Koen Van Aken | Zendy; Yuhan Sun | Zendy; Hannes P. L. Gemoets | Zendy; Timothy Noël | Zendy

Open Access

Optimization of a Decatungstate-Catalyzed C(sp³)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

Author(s) -

Zhenghui Wen,

Apoorva Maheshwari,

Carlo Sambiagio,

Yuchao Deng,

Gabriele Laudadio,

Koen Van Aken,

Yuhan Sun,

Hannes P. L. Gemoets,

Timothy Noël

Publication year - 2020

Publication title -

organic process research and development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 109

eISSN - 1520-586X

pISSN - 1083-6160

DOI - 10.1021/acs.oprd.0c00235

Subject(s) - alkylation , catalysis , reagent , residence time (fluid dynamics) , chemistry , photochemistry , substrate (aquarium) , photocatalysis , continuous reactor , organic chemistry , oceanography , geotechnical engineering , engineering , geology

Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C-H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp 3 )-H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research