Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply | Zendy

Chris De Savi | Zendy; David L. Hughes | Zendy; Lisbet Kværnø | Zendy

Open Access

Quest for a COVID-19 Cure by Repurposing Small-Molecule Drugs: Mechanism of Action, Clinical Development, Synthesis at Scale, and Outlook for Supply

Author(s) -

Chris De Savi,

David L. Hughes,

Lisbet Kværnø

Publication year - 2020

Publication title -

organic process research and development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 109

eISSN - 1520-586X

pISSN - 1083-6160

DOI - 10.1021/acs.oprd.0c00233

Subject(s) - repurposing , covid-19 , clinical trial , drug repositioning , drug development , pandemic , medicine , drug , mechanism (biology) , intensive care medicine , pharmacology , outbreak , virology , engineering , philosophy , disease , epistemology , infectious disease (medical specialty) , waste management

The outbreak of the COVID-19 pandemic has spurred an intense global effort to repurpose existing approved drugs for its treatment. In this review, we highlight the development of seven small-molecule drugs that are currently being assessed in clinical trials for the treatment of COVID-19. Three sections are presented for each drug: (1) history, mechanism of action, and status of clinical trials; (2) scalable synthetic routes and final forms; and (3) outlook for supply should clinical trials show treatment efficacy. A brief overview of diagnostic testing and vaccine development is also presented.

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